2018年11月,,我校李思進(jìn)教授團(tuán)隊(duì)的李莉博士在Science數(shù)據(jù)庫(kù)Q1區(qū)雜志《European Journal of Nuclear Medicine and Molecular Imaging》(歐洲核醫(yī)學(xué)與分子影像,,EJNMMI)發(fā)表一篇關(guān)于冠狀動(dòng)脈斑塊攝取18F-NaF的定量分析及其在斑塊風(fēng)險(xiǎn)預(yù)測(cè)價(jià)值的臨床研究(Li L, Li X, Jia Y, Fan J, Wang H, Fan C, Wu L, Si X, HaoX, Wu P, Yan M, Wang R, Hu G, Liu J, Wu Z, Hacker M, Li S. Sodium-fluoridePET-CT for the non-invasive evaluation of coronary plaques in symptomaticpatients with coronary artery disease: a cross-correlation study withintravascular ultrasound. Eur J Nucl Med Mol Imaging, 2018;45(12):2181–2189),,很快得到國(guó)際學(xué)者們的廣泛關(guān)注,。

該論文發(fā)表的下一期EJNMMI雜志刊登了日本學(xué)者Nakahara T.,美國(guó)學(xué)者Narula J.,,Strauss H.W.等對(duì)該研究的述評(píng)(NakaharaT., Narula J., Strauss H.W.. NaF uptake in unstable plaque: what does fluorideuptake mean? Eur J Nucl Med Mol Imaging, 2018; 45(13):2250–2252),,充分肯定了該研究所揭示的冠脈斑塊NaF攝取高低與冠脈不穩(wěn)定斑塊的風(fēng)險(xiǎn)密切相關(guān)的成果及18F-NaF PET顯像在冠脈不穩(wěn)定斑塊風(fēng)險(xiǎn)預(yù)測(cè)方面具有獨(dú)特價(jià)值。Nakahara T.等指出,,該研究采用18F-NaF PET評(píng)估斑塊內(nèi)的微鈣化成分及含量,,并以IVUS(coronary intravascular ultrasound,,冠脈血管內(nèi)超聲)—VH(組織虛擬學(xué))技術(shù)識(shí)別易損斑塊內(nèi)成分并定量分析,揭示了冠脈內(nèi)易損斑塊攝取18F-NaF與IVUS檢測(cè)結(jié)果的相關(guān)性,,證明了18F-NaF攝取與斑塊負(fù)荷的嚴(yán)重程度,、陽(yáng)性病變重塑和斑塊中心壞死程度呈正相關(guān),與斑塊的纖維化呈負(fù)相關(guān),,18F-NaF強(qiáng)攝取常位于伴有嚴(yán)重鈣化的動(dòng)脈粥樣硬化病變邊緣區(qū)域等,,18F-NaF顯像具有鑒別微鈣化斑塊是否存在活動(dòng)炎性反應(yīng)的能力,這大大改變了我們對(duì)斑塊中鈣化沉積的預(yù)測(cè),,預(yù)防或不良后果等臨床意義的理解,,18F-NaF PET在早期識(shí)別冠脈易損斑塊及預(yù)測(cè)未來心血管不良事件方面有較大的潛在價(jià)值。
原文鏈接:Li L, Li X, Jia Y, Fan J, Wang H, Fan C, Wu L, Si X, HaoX, Wu P, Yan M, Wang R, Hu G, Liu J, Wu Z, Hacker M, Li S. Sodium-fluoridePET-CT for the non-invasive evaluation of coronary plaques in symptomaticpatients with coronary artery disease: a cross-correlation study withintravascular ultrasound. Eur J Nucl Med Mol Imaging, 2018;45(12):2181–2189.
NakaharaT., Narula J., Strauss H.W.. NaF uptake in unstable plaque: what does fluorideuptake mean? Eur J Nucl Med Mol Imaging, 2018; 45(13):2250–2252.
(圖文/王曉暉)