
唐莉
博士,,副教授,,碩士生導師,藥學院藥物化學教研室主任
E-mail: [email protected]
教育經歷
2009年09月—2013年06月 山西醫(yī)科大學,,博士
2006年09月—2009年06月 山西醫(yī)科大學,,碩士
2002年09月—2006年06月 山西醫(yī)科大學,學士
工作經歷
2019年01月—今 山西醫(yī)科大學,,副教授
2013年11月—2018年12月 山西醫(yī)科大學,,講師
學術任職
山西省藥品審評專家
山西省藥學會藥物分析專業(yè)委員會秘書
榮譽獲獎
山西省科學技術獎自然科學類二等獎(編號:2019-Z-2-015),排名第二
2018年度山西省“三晉英才”支持計劃青年優(yōu)秀人才
山西省第十一次社會科學研究優(yōu)秀成果三等獎,,排名第三
山西醫(yī)科大學第十七屆“三育人”先進個人
教學情況
承擔藥學,、中藥學、臨床藥學專業(yè)本科生《有機化學》,、《有機化學實驗》的教學工作
研究領域
藥物設計合成,、活性篩選、藥效學評價及其作用機制研究,。
代表性科研,、教改項目
1、國家自然科學基金,,具有可調控TNF-α與IL-1介導的信號通路的新型苯并唑酮抗炎小分子化合物庫的構建及其作用機制研究(81602976),,2017/01-2019/12,17萬,,主持
2,、山西省青年科技研究基金優(yōu)秀青年基金項目,靶向巨噬細胞的W3D納米微球的制備及其抗類風濕性關節(jié)炎的活性研究(201901D211350) ,,2019/09-2022/09,,15萬,主持3,、山西省青年科技研究基金,,具有高效抗炎活性的新結構化合物MBB的作用機制及其靶點研究(201601D021159) ,,2016/07-2018/12,3萬元,,主持,。
4、山西省高等學??萍紕?chuàng)新項目,,新型鎮(zhèn)痛抗炎化合物MBB對膠原誘導性關節(jié)炎大鼠的作用機制研究(2014132),2014/06-2016/06,,4萬元,,主持。
代表性論著
1,、Rui Ge, Qikai Su, Jian Liang, Lu Zheng, Qing-shan Li, Li Tang*. Dulcitol ameliorates LPS-induced acute lung injury (ALI) in mice by inhibiting TLR4/NF-κB activation. Journal of Functional Foods, 2025, 128:106797.
2,、Rui Ge, Jiaqi Song, Zhen Cao, Shurong Ban, Li Tang*, Qing-shan Li*. Discovery of 6-Acylamino/Sulfonamido Benzoxazolone with IL-6 Inhibitory Activity as Promising Therapeutic Agents for Ulcerative Colitis. Chemistry & Biodiversity. 2024,
3、Huiying Bai, Zhen Cao, Sha Meng, Rui Ge, Shurong Ban, Yuanlin Zhang, Li Tang*, Qing-Shan Li*, Synthesis and Anti-Inflammatory Activity Evaluation of Benzoxazole Derivatives as New Myeloid Differentiation Protein 2 Inhibitors, Chemistry & Biodiversity. 2023
4,、Sha Meng, Zhen Cao, Huiying Bai, Rui Ge, Shurong Ban, Li Tang*, Qing-shan Li*. Antinociceptive Action of 4-(5′-Dimethylamino)- Naphthalenesulfonyl-2(3H)-Benzoxazolone (W3D) on Animal Models of Pain via Inhibitory Effects on NO and iNOS. Natural Product Communications, 2023, 18(10):1-9.
5,、Li Tang#, Xiao-hui Gao#, Bei Zhao#, Jie-ran Luo, Xin-yang Shi, Rui Ge, Shu-rong Ban, Qing-shan Li*, Design and synthesis of new disubstituted benzoxazolone derivatives that act as iNOS inhibitors with potent anti-inflammatory activity against LPS induced acute lung injury (ALI), Bioorganic & Medicinal Chemistry, 2020, 28: 115733-115743.
6、Li Tang#, Jie-ran Luo#, Dai-tian Li#, Rui Ge, Yun-long Ma, Fei Xu, Tai-gang Liang, Shu-rong Ban, Qing-shan Li*, Anti-inflammatory effects of 4-o-methyl-benzenesulfonyl benzoxazolone (MBB) in vivo and in vitro as a novel NSAIDs lead compound, Pharmacological Reports, 2018, 70: 558-564.
7,、Li Tang#, Jie-ran Luo#, Yun-lan Li, Rui Ge, Qing-Shan Li*,,Hepatotoxicity and proteomic mechanism of Di-n-butyl-di-(4-chlorobenzohydroxamato)tin(IV) (DBDCT) in vivo,Environmental Toxicology and Pharmacology,,2017, 51: 38-44.
8,、Xiao-xia Liu, Li Tang, Rui Ge, Jian-kuan Li, Ya Kang, Mei-xia Zhu, Qing Shan Li*, Xu-liang Hao*. iTRAQ-based quantitative proteomic analysis of the anti-apoptotic effect of hyperin, which is mediated by Mcl-1 and Bid, in H2O2-injured EA.hy926 cells. International Journal of Molecular Medicine. 2016, 37:1083-1090
9、Li Tang, Wen-Hua Ma, Yun-Long Ma, Shu-Rong Ban, Xiu-E Feng, Qing-Shan Li. Synthesis and biological activity of 4-substituted benzoxazolone derivatives as a new class of sEH inhibitors with high anti-inflammatory activity in vivo. Bioorganic & Medicinal Chemistry Letters. 2013, 23: 2380-2383.
10,、Li Tang, Yun-lan Li, Rui Ge, Qing-Shan Li. Oxidative stress in di-n-butyl-di-(4-chlorobenzohydroxamato)tin (IV)-induced hepatotoxicity determined by proteomic profiles. Toxicology Letters. 2012, 213: 167–173.