閆超群

博士,，碩士生導(dǎo)師,，臨床藥學(xué)教研室副教授

E-mail: [email protected]

教育經(jīng)歷

2015年9月—2020年6月 山西醫(yī)科大學(xué),，臨床藥學(xué),，博士

2012年9月—2015年6月 山西醫(yī)科大學(xué)，藥物化學(xué),，碩士

2008年9月—2012年6月 山西醫(yī)科大學(xué),，藥學(xué)，學(xué)士

工作經(jīng)歷

2020年9月—至今 山西醫(yī)科大學(xué),，藥學(xué)院,，講師

榮譽(yù)獲獎(jiǎng)

2024年度山西醫(yī)科大學(xué)青年教師教學(xué)競(jìng)賽決賽（醫(yī)科組）三等獎(jiǎng)

2024年度山西醫(yī)科大學(xué)大學(xué)生創(chuàng)新大賽三等獎(jiǎng)（指導(dǎo)教師）

2024年度山西醫(yī)科大學(xué)青年教師教學(xué)競(jìng)賽藥學(xué)院一等獎(jiǎng)

2020年度校級(jí)優(yōu)秀研究成果期刊論文類三等獎(jiǎng)

教學(xué)情況

研究生課程《高等臨床藥學(xué)》負(fù)責(zé)人，講授《藥物治療學(xué)》《生物藥劑學(xué)》《藥事管理》《藥物流行病學(xué)》等課程,。

研究領(lǐng)域

主要從事天然來(lái)源活性小分子化合物的結(jié)構(gòu)優(yōu)化,、特異性親和蛋白篩選、小分子化合物與蛋白相互作用機(jī)制及相關(guān)理論化學(xué)計(jì)算,、基于小分子化合物特異性親和蛋白的生物活性作用機(jī)制研究,。

代表性科研,、教改項(xiàng)目

1、國(guó)家自然科學(xué)基金委員會(huì),，青年科學(xué)基金項(xiàng)目,，82104171，杜鵑素靶向調(diào)控GSK3β/Nrf2介導(dǎo)的鐵死亡改善血栓閉塞性脈管炎內(nèi)皮損傷的機(jī)制研究,，2022-01至2024-12，30萬(wàn)元,，結(jié)題,，主持。

2,、山西省教育廳,，2021年山西省高等學(xué)校科技創(chuàng)新項(xiàng)目,，杜鵑素靶向調(diào)控GSK3β/AMPK介導(dǎo)的自噬改善血栓閉塞性脈管炎內(nèi)皮損傷的機(jī)制研究,，2022-01至2023-12，2萬(wàn)元,，結(jié)題,，主持。

3,、山西省科技廳,，2021年山西省基礎(chǔ)研究計(jì)劃（自由探索類）項(xiàng)目，杜鵑素靶向調(diào)控GSK3β/Nrf2介導(dǎo)的鐵死亡改善血栓閉塞性脈管炎內(nèi)皮損傷的機(jī)制研究,，2022-01至2024-12,，4萬(wàn)元，在研,，主持,。

4、山西省教育廳,，山西省研究生教育創(chuàng)新項(xiàng)目,，2017BY084，杜鵑素內(nèi)皮細(xì)胞保護(hù)作用靶點(diǎn)的初步研究,，2017-06至2020-06,，1萬(wàn)元，結(jié)題,，主持,。

代表性論著

1、Minfan Pei#, Aiyun Qian#, Li Cao, Zhenfang Wang, Yiping Lu, Chaoqun Yan*, Taigang Liang*. In silico design of novel potential isonicotinamide-based glycogen synthase kinase-3β (GSK-3β) inhibitors: 3D-QSAR, molecular docking, molecular dynamics simulation and ADMET studies. [J]. New Journal of Chemistry. 2025.

2,、Liwei Wang, Lu Zhang, Yang Yun, Tingting Liang, Chaoqun Yan, Zhuoya Mao, Jingfang Zhang, Baoshe Liu*, Jian Zhang, Taigang Liang*. Protective effect of astragaloside IV against zinc oxide nanoparticles induced human neuroblastoma SH-SY5Y cell death: a focus on mitochondrial quality control. [J]. Molecular and Cellular Biochemistry (2024): 1-17.

3,、Yidan Sun, Chaoqun Yan, Tingting Liang, Wen Li, Minfan Pei, Linyan Zhang, Qingshan Li, Taigang Liang*. Comparative study on interactions of phillyrin and phillygenol with lysozyme: Spectroscopy, differential scanning calorimetry and molecular modeling approaches. [J]. Journal of Molecular Liquids, 2024: 124571.

4,、Chungiang Wang, Yuzhu Fan, Minfan Pei, Chaoqun Yan, Taigang Liang*, 3D and 2D-QSAR Studies on Natural Flavonoids for Nitric Oxide Production Inhibitory Activity. [J]. Letters in Drug Design & Discovery, 2024.

5、梁婷婷,，張璐,，閆超群，梁泰剛*.N-取代馬來(lái)酰亞胺類hMGL抑制劑的3D-QSAR,、分子對(duì)接和分子動(dòng)力學(xué)研究. [J]. 化學(xué)通報(bào), 2024.

6,、Dongxiao Cui, Dingqiao Xu, Shijun Yue, Chaoqun Yan, Wenjuan Liu, Ruijia Fu, Wenfu Ma, Yuping Tang. Recent advances in the pharmacological applications and liver toxicity of triptolide[J]. Chemico-Biological Interactions, 2023: 110651.

7、Junqiu Miao, Jing Shen, Chaoqun Yan, Jinhong Ren, Haixin Liu, Yuanbiao Qiao, Qingshan Li*. The protective effects of Mai-Luo-Ning injection against LPS-induced acute lung injury via the TLR4/NF-κB signalling pathway. [J]. Phytomedicine, 2022,104, 154290.

8,、Wen Li, Yuzhu Fan, Chaoqun Yan, YanDu, Tingting Liang, Chunqiang Wang, Liwei Wang, Lingling Han, Qingshan Li*, Taigang Liang*. Triptolide and Methotrexate Binding Competitively to Bovine Serum Albumin: A Study of Spectroscopic Experiments, Molecular Docking, and Molecular Dynamic Simulation[J]. Journal of Molecular Liquids, 2022,367:120300.

9,、Liwei Wang, Zhiyu Duan, Madan Liang, Chunqiang Wang*, Tingting Liang, Liqian Sun, Chaoqun Yan, Qingshan Li*, Taigang Liang*. A pivotal role of selective autophagy in mitochondrial quality control: Implications for zinc oxide nanoparticles induced neurotoxicity[J]. Chemico-Biological Interactions, 2022,363: 110003.

10、Zhiyu Duan, Madan Liang, Congcong Yang, Chaoqun Yan, Liwei Wang, Jiaqi Song, Lingling Han, Yuzhu Fan, Wen Li, Taigang Liang*, Qingshan Li*. Selenium nanoparticles coupling with Astragalus Polysaccharides exert their cytotoxicities in MCF-7 cells by inhibiting autophagy and promoting apoptosis[J]. Journal of Trace Elements in Medicine and Biology, 2022: 127006. 2022,73: 127006

11,、Lingling Han, Jiaqi Song, Chaoqun Yan, Chunqiang Wang, Liwei Wang, Wen Li, Yan Du, Qingshan Li*, Taigang Liang*. Inhibitory activity and mechanism of calycosin and calycosin-7-O-β-D-glucoside on α-glucosidase: Spectroscopic and molecular docking analyses[J]. Process Biochemistry, 2022. 2022,118:227-235.

12,、Chaoqun Yan, Jiali Zhang, Taigang Liang*, Qingshan Li*. Diorganotin (IV) complexes with 4-nitro-N-phthaloyl-glycine: Synthesis, characterization, antitumor activity and DNA-binding studies. [J]. Biomedicine & Pharmacotherapy, 2015, 71: 119-127.

13、Xiaoyan Zhang1, Taigang Liang1, Wanxia Yang, Lanfang Zhang, Shuting Wu, Chaoqun Yan, Qingshan Li*. Astragalus membranaceus injection suppresses production of interleukin-6 by activating autophagy through the AMPK-mTOR pathway in lipopolysaccharide-stimulated macrophages[J]. Oxidative medicine and cellular longevity, 2020, 2020.

14,、Dongxiao Cui, Chaoqun Yan, Junqiu Miao, Xiaoyan Zhang, Jingrun Chen, Liqian Sun, Liqiang Meng, Taigang Liang*, Qingshan Li*. Synthesis, characterization and antitumor properties of selenium nanoparticles coupling with ferulic acid. [J]. Materials Science & Engineering C, 2018, 90: 104-112.

15,、Liqiang Meng, Liqian Sun, Chaoqun Yan, Dongxiao Cui, Jingrun Chen, Taigang Liang*, Qingshan Li*. 3D QSAR studies of tricyclic compounds as Porcupine Inhibitors for Wnt pathway inhibitory activity. [J]. Letters in Drug Design & Discovery, 2018, 15(7): 721-732.

16、Liqian Sun, Liqiang Meng, Chaoqun Yan, Dongxiao Cui, Junqiu Miao, Jingrun Chen, Taigang Liang*, Qingshan Li*. 3D-QSAR Studies on 4-([1,2,4]Triazolo[1,5-α]pyridin-6-yl)-5(3)-(6-methylpyridin-2-yl)imidazole Analogues as Potent Inhibitors of Transforming Growth Factor-β Type I Receptor Kinase. [J]. Chinese Journal of Structural Chemistry, 2018, 37(4): 517-530.

17,、Xiaorui Wang, Junqiu Miao, Chaoqun Yan, Rui Ge, Taigang Liang*, Enli Liu, Qingshan Li*. Chitosan attenuates dibutyltin-induced apoptosis in PC12 cells through inhibition of the mitochondria-dependent pathway. [J]. Carbohydrate Polymers, 2016, 151: 996-1005.

18,、Taigang Liang#, Chaoqun Yan#, Li Yang, Mengnan Hu, Shurong Ban, Qingshan Li*. 3D-QSAR studies of 8-substituted chromen-4-one-2-carboxylic acid derivatives as potent agonists for the orphan G protein-coupled receptor 35. [J]. Medicinal Chemistry Research, 2015, 24(5): 2183-2194.