暢瑞苗

醫(yī)學(xué)博士學(xué)位,，副教授,，碩士生導(dǎo)師，藥物分析教研室

E-mail: [email protected]

教育經(jīng)歷

2013年9月—2016年12月 西安交通大學(xué)，博士

2010年9月—2013年7月 山西醫(yī)科大學(xué),，碩士

2006年9月—2010年7月 山西醫(yī)科大學(xué),，學(xué)士

工作經(jīng)歷

2023年12月—今 山西醫(yī)科大學(xué) 副教授

2022年3月—今 山西白求恩醫(yī)院 博士后

2016年12月—2023年12月 山西醫(yī)科大學(xué) 講師

學(xué)術(shù)任職

雜志《西北藥學(xué)》,、《Nano Biomedicine and Engineering》青年編委,。

榮譽(yù)獲獎(jiǎng)

全國(guó)醫(yī)學(xué)類微課教學(xué)比賽三等獎(jiǎng)。

教學(xué)情況

主要承擔(dān)研究生《現(xiàn)代藥物分析方法與技術(shù)》,、本科生《藥物分析》理論及實(shí)驗(yàn)課程,、本科生《中藥制劑分析》實(shí)驗(yàn)課程、藥學(xué)專升本《藥物分析》理論課程的教學(xué),。

研究領(lǐng)域

主要從事基于miRNA中藥活性成分篩選及心腎藥效研究,、中藥活性成分分離分析、難溶性藥物增溶等方面的科研工作,。

代表性科研、教改項(xiàng)目

1,、黃芪調(diào)控miR-21活性物質(zhì)的快速發(fā)現(xiàn)及其對(duì)心肌纖維化ERK-MAPK通路的影響,，中國(guó)博士后科學(xué)基金第73批面上資助，8萬(wàn)元,。項(xiàng)目負(fù)責(zé)人,，在研。

2,、黃芪中靶向miR-21成熟過(guò)程關(guān)鍵核酸的活性成分快速發(fā)現(xiàn)及其抗心衰作用研究,，國(guó)家自然科學(xué)基金（青年），30萬(wàn)元,。項(xiàng)目負(fù)責(zé)人,，在研。

3,、以mi-RNA 21為靶點(diǎn)的黃芪抗心衰活性組分可視化垂釣新方法構(gòu)建,。山西省基礎(chǔ)研究計(jì)劃,，5萬(wàn)元。項(xiàng)目負(fù)責(zé)人,，結(jié)題,。

4、山西醫(yī)科大學(xué)教育教學(xué)研究課題,，一般性課題：基于OBE理念的藥學(xué)本科畢業(yè)論文指導(dǎo)方法研究與實(shí)踐,，項(xiàng)目負(fù)責(zé)人，在研,。

5,、環(huán)境暴露微血管病變防治，山西省科技創(chuàng)新人才團(tuán)隊(duì)（青年）,，100萬(wàn)元,。項(xiàng)目核心人員，在研,。

6,、基于新型“雙增敏”策略的樣品前處理技術(shù)耦合SFC-MS的FAHFAs分析體系構(gòu)建，山西省基礎(chǔ)研究計(jì)劃面上項(xiàng)目,，10萬(wàn)元,。項(xiàng)目核心人員，在研,。

7,、基于新型功能化離子液體的HPCE分離體系研究及其在臨床手性藥物分析中的應(yīng)用，山西省衛(wèi)生健康委員會(huì)醫(yī)學(xué)重點(diǎn)科技項(xiàng)目,，15萬(wàn)元,。項(xiàng)目核心人員，結(jié)題,。

代表性論著

1. Ruimiao Chang#, Xinying Qu#, Yuting Ye, Ying Qu, Bingyang Chu*, Zhiyong Qian*. Current advances in nanomedicine-based therapies for acute kidney injury. Chinese Chemical Letters, 2024, 394, 110802.

2. Ruimiao Chang, Huichun Wang, Shumian Liu, Yijing Dong, Guangbin Zhang, Anjia Chen, Ruiping Zhang*, Yong Li*. Modifying of magnetic UiO-66-NH2 as a new nanosorbent by thermo-alkali-hydrolysis technology for highly efficient enrichment and determination of quercetin in apple peel[J]. Separation and Purification Technology, 2025, 353: 128054.

3. Meiyi Wang, Junzhao Ren, Guangbin Zhang, Hongfen Zhang, Ruimiao Chang, Haixia Yu*, Anjia Chen*. Simultaneous separation and determination of seven biphenyl cyclooctene lignans in Schisandra chinensis and its preparations by micellar electrokinetic chromatography with dual organic solvent system[J]. Phytochemical Analysis, 2024;1-10.

4. 暢瑞苗, 張艷洋, 康安娟, 張廣彬, 余彥平, 任俊照, 陳安家, 李勇. 熱堿解改性UiO-66材料對(duì)槲皮素的裝載,、釋放及抗氧化作用研究[J]. 藥學(xué)學(xué)報(bào), 2023, 58(9): 2802-2810.

5. Rui Miao Chang, Yan Yang Zhang, Guang Bin Zhang, Xiao Xia Zhang, An Jia Chen, Wen Zhang, Yong Li. Application of thermal alkaline hydrolysis technology to improve the loading and in-vitro release of gallic acid in UiO-66[J]. Food Chemistry, 2022, 391: 133238.

6. Hua Wang#, Yuhang Yang#, Jing Guo, Mengli Wang, Hongfen Zhang, Guangbin Zhang, Ruimiao Chang*, Anjia Chen*. Simultaneous separation and determination of four active ingredients in Picria fel-terrae Lour. and its preparations by micellar electrokinetic chromatography[J]. Phytochemical Analysis, 2021, 32(6): 1110-1117.

7. Yang Yuhang#, Wang Hua#, Yu Haixia, Zhang Hongfen, Zhang Guangbin, Chang Ruimiao*, Chen Anjia*. Simultaneous separation and determination of three huperzine alkaloids in Huperzia serrata and its preparations by cyclodextrin-modified mixed micellar electrokinetic capillary chromatography[J]. Analytical Biochemistry, 2021, 623: 114207.

8. Mengli Wang, Jing Guo, Zhiying Wang, Guangbin Zhang, Haixia Yu, Ruimiao Chang*, Anjia Chen*. Simultaneous separation and determination of hirsutine and hirsuteine by cyclodextrin-modified micellar electrokinetic capillary chromatography[J]. Phytochemical analysis. 2020, 31: 112-118.

9. Haitao Guo, Zhiying Wang, Liying Xu, Hongfen Zhang, Ruimiao Chang*, Anjia Chen*. Separation and simultaneous determination of seven bioactive components in, Tripterygium wilfordii, Hook.F. and, Tripterygium, preparations by micellar electrokinetic capillary chromatography[J]. Electrophoresis 2019, 40, 547-554.

10. Jing Guo, Mengli Wang, Haitao Guo, Ruimiao Chang, Haixia Yu, Guangbin Zhang*, Anjia Chen*. Simultaneous separation and determination of seven isoflavones in Radix Puerariae by capillary electrophoresis with a dual cyclodextrin system[J]. Biomedical Chromatography. 2019; e4646.

11. Zhiying Wang, Haitao Guo, Meng Chen, Guangbin Zhang, Ruimiao Chang*, Anjia Chen*. Separation and determination of corynoxine and corynoxine b using chiral ionic liquid and hydroxypropyl-β-cyclodextrin as additives by field-amplified sample stacking in capillary electrophoresis[J], Electrophoresis, 2018, 39(17): 2195-2201.

12. Ruimiao Chang, Qiang Fu, Yong Li, Mingchan Wang, Wei Du, Chun Chang, Aiguo Zeng*. Crystallization and relaxation dynamics of amorphous loratadine under different quench-cooling temperatures[J]. CrystEngComm, 2017, 19(2): 335-345.

13. Ruimiao Chang, Qiang Fu, Pei Yu, Lu Wang, Wei Du, Chun Chang, Aiguo Zeng*. A new polymorphic form and polymorphic transformation of loratadine[J]. RSC Advances, 2016, 6(88): 85063-85073.

14. Ruimiao Chang, Aiguo Zeng, Wei Du, Xinya Xu, Saijie Zuo, Chun Chang, Qiang Fu*. An HPLC method for the determination of a novel anti-hypertension agent 6,7-dimethoxy-3-(4-(4-fluorobenzyloxy)-3-methoxyphenylmethyl) quinazolin-4(3H)-one in rat plasma: application to pharmacokinetic study[J]. Biomedical Chromatography, 2016, 30(7): 1118-1123.

15. Chen M, Chang RM, Xu LY, Huang YY, Zhang HF*, Chen AJ*. Simultaneous separation and determination of praeruptorin A, B and C by micellar electrokinetic chromatography using sodium dodecyl sulfate and sodium cholate as mixed micelles[J]. Phytochemical Analysis, 2018, 29(5): 425-431.

16. Xu LY, Chang RM, Chen M, Li L, Huang YY, Zhang HF*, Chen AJ*. Quality evaluation of Guan-Xin-Ning injection based on fingerprint analysis and simultaneous separation and determination of seven bioactive constituents by capillary electrophoresis[J]. Electrophoresis, 2017, 38(24): 3168-3176.

17. Wang J, Chang RM, Zhang JY, Zhang T, Fu Q, Chang C, Zeng AG*. Coamorphous loratadine-citric acid system with enhanced physical stability and bioavailability[J]. AAPS PharmSciTech, 2017: 1-10.