郭麗霞

山西醫(yī)科大學(xué)藥學(xué)院藥物化學(xué)教研室,，講師,，理學(xué)博士

E-mail:[email protected]

教育經(jīng)歷

2015年9月—2020年7月 山西大學(xué)，博士（碩博連讀）

2011年9月—2015年7月 太原師范學(xué)院，學(xué)士

工作經(jīng)歷

2022年3月—至今 在站博士后,，山西醫(yī)科大學(xué)第三臨床醫(yī)學(xué)院

2020年9月—至今 山西醫(yī)科大學(xué),，藥學(xué)院,，講師

榮譽(yù)獲獎(jiǎng)

山西省自然科學(xué)二等獎(jiǎng),，山西省科技廳，2022

教學(xué)情況

主要承擔(dān)承擔(dān)了《有機(jī)化學(xué)》,、《化學(xué)生物學(xué)》《藥學(xué)進(jìn)展》的教學(xué),，以及有機(jī)化學(xué)和藥物化學(xué)的實(shí)驗(yàn)準(zhǔn)備工作。

研究領(lǐng)域

聚焦于有機(jī)功能分子的設(shè)計(jì),、合成,，以及納米自組裝體的構(gòu)建,，致力于其在疾病診斷、抗菌領(lǐng)域的應(yīng)用,。在有機(jī)功能分子設(shè)計(jì)合成方面,，構(gòu)建具有特定光學(xué)、電學(xué)或化學(xué)活性的有機(jī)分子,，利用其對生物標(biāo)志物的特異性識(shí)別能力,，實(shí)現(xiàn)疾病的早期精準(zhǔn)診斷；設(shè)計(jì)合成具有抗菌活性的有機(jī)分子及納米自組裝體,，探索其對耐藥菌的作用機(jī)制，為解決抗生素耐藥問題提供新思路,。

代表性科研,、教改項(xiàng)目

1、中國博士后科學(xué)基金面上資助,，中國博士后科學(xué)基金會(huì),，8萬元，在研,，主持,。

2、山西省博士啟動(dòng)基金,，5萬,，在研，主持,。

3,、山西省自然科學(xué)基金青年項(xiàng)目，山西省科技廳,，5萬元,，結(jié)題，主持,。

代表性論著

1,、發(fā)表論文：

(1) Lixia Guo, Xiaowan Li, Run Zhang, Yixuan Hou, Bolong Ma, Zheng Li, Jiye Lv, Bin Wang, Sufang Ma, Lihong Li, Lili Yan, Boye Zhang, Wen Liu, Kahleong Lim, Haipeng Diao*, Shaowei Wang*, Chengwu Zhang*. In situ dual-activated NIRF/PA carrier-free nanoprobe for diagnosis and treatment of Parkinson’s disease. Biosensors and Bioelectronics, 2025, 282, 117473.

(2) Lixia Guo, Xiaowan Li, Shangyu Xie, Baizhi Su, Na Yang, Bin Wang, Sufang Ma, Lihong Li, Lili Yan, Boye Zhang, Wen Liu, Kahleong Lim, Yang Liu*, Haipeng Diao*, Chengwu Zhang*. Double-locked probe for NIRF/PA imaging mitochondrial H2O2 and viscosity in Parkinson’s disease. Sensors & Actuators: B. Chemical, 2025, 205, 111370.

(3) Lixia Guo, Yafei Tian, Liang Zhou, Shiyue Kang, Chengwu Zhang, Wen Liu, Haipeng Diao, Liheng Feng. Tailored phototherapy agent by infection site in situ activated against methicillin-resistant S. aureus. Advanced Healthcare Materials, 2024, 2400593.

(4) Lixia Guo, Jiahuan Liu, Xiaowan Li, Yinyu Ma, Shiyue Kang, Yafei Tian, Bin Wang, Sufang Ma, Lihong Li, Lili Yan, Chengwu Zhang, Wen Liu, Haipeng Diao*, Shurong Ban*, Ruiping Zhang*, Liheng Feng*. An activatable NIR fluorescent/photoacoustic probe for rapid identification of β-lactam-resistant bacteria，Microchemical Journal, 2024, 205, 111368.

(5) Jiahuan Liu, Xiaowan Li, Shangyu Xie, Ruirui Ma, Hongfei Wang, Shurong Ban*, Chengwu Zhang*, Lixia Guo*. Fabricating a PDA-NOate@CuS coated NIR-activatable titanium implant to realize simultaneous antiinfection and osseointegration. New Journal of Chemistry, 2024, 48, 11465-11475.

(6) Lixia Guo, Xueyun Zhang, Danning Wen, Lei Ding, Yan Niu, Lihong Li, Wen Liu, Haipeng Diao*, Liheng Feng*. A Novel Two-channel Ratio Fluorescent Probe for Monitoring Intracellular pH Fluctuations. Sensors and Actuators B: Chemical, 2022, 360, 131656.

(7) Lixia Guo, Haoping Wang, Yunxia Wang*, Feng Liu*, Liheng Feng*. Organic Polymer Nanoparticles with Primary Ammonium Salt as Potent Antibacterial Nanomaterials. ACS Applied Materials & Interfaces, 2020, 12, 21254?21262.

(8) Lixia Guo, Haoping Wang, Yunxia Wang*, Liheng Feng*. Tailor-Made Polymer Nano-Assembly with Switchable Function and Amplified Anti-Tumor Therapy. Advanced Healthcare Materials, 2019, 1901492.

(9) Lixia Guo, Haoping Wang, Yunxia Wang*, Liheng Feng*. Facile core-shell nanoparticles with controllable antibacterial activity assembled by chemical and biological molecules. Biomaterials Science, 2019, 7, 5528-5534.

(10) Lixia Guo, Xiaoju Wang, Liheng Feng*. Synthesis, photophysical and electrochemical properties of a blue emitter with binaphthalene and carbazole units. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2018, 201, 376-381.

(11) Liheng Feng*, Lixia Guo, Xiaoju Wang. Preparation, properties and applications in cell imaging and ions detection of conjugated polymer nanoparticles with alcoxyl bonding fluorene core. Biosensors and Bioelectronics, 2017, 87, 514-521.

(12) Xiaoju Wang#, Lixia Guo#, Liheng Feng*. A multi stimuli responsive material with rhodamine B and carbazole groups. New Journal of Chemistry, 2019, 43, 4181-4187.

(13) Tao Qin#, Lixia Guo#, Haipeng Diao*, Liheng Feng*. Facile Antibacterial Materials with Turbine-like Structure for P. aeruginosa Infected Scald Wounds Healing. Biomaterials Science, 2021, 9, 3830.

2,、授權(quán)專利

(1) 郭麗霞,，劉文，田亞飛,，李錦瑤,，任國棟，馬素芳,，張承武,，李麗紅，刁海鵬，王浩江,，王斌,，閆麗麗. 一種檢測耐藥菌中β-內(nèi)酰胺酶的近紅外熒光探針的制備, 專利號：ZL202211255743.4，授權(quán)日：2023-08-29,。

(2) 郭麗霞,，馮麗恒. 具有可視化診斷和治療感染傷口的溫敏水凝膠及制備方法，專利號：ZL201911364220.1,，授權(quán)日：2021.3.30,。

(3) 馮麗恒，郭麗霞. 一種藍(lán)光發(fā)光材料及其制備方法. 國內(nèi)發(fā)明專利,，專利號：ZL201610200923.0,，授權(quán)日：2017.11.3。

(4) 馮麗恒,，郭麗霞. 一種環(huán)狀聚合物及其制備方法和應(yīng)用. 國內(nèi)發(fā)明專利,，專利號：ZL201810189654.1，授權(quán)日：2020.2.14,。